By I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins

  • ''...the quantity definitely succeeds total as an in-depth survey of either the biology and the biochemistry of a ubiquitous and astonishingly diversified relations of very advanced enzymes. each crew with an curiosity in those proteins may still personal a copy.'' -CELL (July 2003) ''The editors of ABC Proteins: From micro organism to Man have valiantly tried to surround during this quantity the full scope of study on those proteins, from atomic-resolution constitution to human genetic illnesses, and from Escherichia coli to Homo sapiens and Arabidopsis thaliana... What the booklet makes seen is that almost all ABC proteins are membrane localized, ATP based, basic lively transporters...In addition to advances in our figuring out of ABC transporter constitution, numerous chapters within the ebook additionally describe growth that has been made in elcuidating the mechanisms of delivery. the amount undoubtedly succeeds total as an in-depth survey of either the biology and the biochemistry of a ubiquitous and astoundingly various kinfolk of very advanced enzymes. each staff with an curiosity in those proteins should still personal a replica. ultimately, this booklet makes a powerful case that many laboratories that will not but suspect it is going to quickly have a way more abiding curiosity in ABC proteins.'' ''...well equipped and incorporated superbly transparent colour photos and figures.'' -E STREAMS (July 2003)

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Nat. Genet. 15, 137–145. C. and Poolman, B. (2001) Peptides and ATP binding cassette peptide transporters. Res. Microbiol. 152, 245–258. , Boos, W. and Welte, W. (2000) Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J. 19, 5951–5961. A. L. (1993) ATPdependent transport systems in bacteria and humans – relevance to cystic fibrosis and multidrug resistance. Annu. Rev. Microbiol. 47, 291–319. K. D. (1998) A multidrug resistance transporter from human MCF-7 breast cancer cells.

Among these, the ABCA subfamily is exceptional in the sense A B The NOD subfamily involved in nodulation Rhizobial lipochito-oligosaccharidic Nod factors mediate specific recognition between leguminous plants and their prokaryotic symbionts. 8. Typical organization of class 3 systems that could be exporters. 2 for the representations of membranes and for the IM and ABC domains. A, Organization of DRA family systems involved in the resistance to polyketide drugs, in nodulation and sodium ion extrusion.

Hum. Mol. Genet. 8, 743–749. F. and Lecar, H. (1992) ATP-dependent bacterial transporters and cystic fibrosis: analogy between channels and transporters. FASEB J. 6, 2660–2666. , Mimura, C. and Shyamala, V. (1990) Bacterial periplasmic permeases belong to a family of transport proteins operating from Escherichia coli to human traffic ATPases. FEMS Microbiol. Rev. 75, 429–446. R. and Shyamala, V. (1992) Traffic ATPases: a superfamily of transport proteins operating from Escherichia coli to humans.

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