By Christian Dani, Nathalie Billon (auth.), Michael E. Symonds (eds.)
This ebook is designed to supply a complete perception into present views and demanding situations in adipose tissue biology. In <i>Adipose Tissue Biology</i>, scientists and clinicians talk about adipocyte precursors, differentiation and progress, brown and white adipose tissue, gender, irritation, nutritional and genetic determinants of fats mass, including evolutionary and developmental facets of adiposity.
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This publication is designed to supply a complete perception into present views and demanding situations in adipose tissue biology. In <i>Adipose Tissue Biology</i>, scientists and clinicians talk about adipocyte precursors, differentiation and progress, brown and white adipose tissue, gender, irritation, nutritional and genetic determinants of fats mass, including evolutionary and developmental facets of adiposity.
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J Biol Chem 279:35503–35509 Lonn M, Mehlig K, Bengtsson C et al (2010) Adipocyte size predicts incidence of type 2 diabetes in women. FASEB J 24:326–331 Lumeng CN, Deyoung SM, Saltiel AR (2007) Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab 292:E166–E174 Masuzaki H, Paterson J, Shinyama H et al (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166–2170 Matsumoto T, Kano K, Kondo D et al (2008) Mature adipocytederived dedifferentiated fat cells exhibit multilineage potential.
6 Future Perspectives This review provides a brief overview on various adipocyte cell lines that could be used in appropriate experiments to gain insight in the molecular mechanisms that underlie adipocyte differentiation. The selection and use of an in vitro system must consider all known levels of regulation of proliferation, differentiation and function to ensure relevant results. The information summarized here concerning intracellular pathways and nuclear and extranuclear modulators of adipocyte differentiation is continuously expanding.
Fromme Fig. 1 Histology of brown and white adipose tissue. A section of paraffin-embedded interscapular brown adipose tissue was treated with haematoxylin to stain nuclei in blue. UCP1 was immunodetected and is indicated by a brownish color. Typical multilocular brown adipocytes positive for UCP1 can be seen in the left half of the picture, while unilocular white adipocytes devoid of UCP1 dominate the right half (image kindly provided by David Lasar) The interscapular brown adipose tissue lobes are surrounded by adhering white adipose tissue which allows direct comparison of brown and white adipocyte morphologies in histological sections (Fig.