By T.K. Ghose ,A. Fiechter, N.Blakebrough

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Rowe, P. : Chem. Eng. Sci. 26, 173 (1971). O'Neill, S. , Wykes, J. , Lilly, M. : Biotech. Bioeng. 13, 319 (1971). Otto, N. , Quinn, J. : Chem. Eng. Sci. 26, 949 (1971). , Jr. 311--321. New York: 1972. , Salamone, J. , Yaroslavsky, S. '. Pure Appl. Chem. 15, 453 (1967). Palit, S. : Sci. Cult. 34, 37 (1968). Pardee, A. : In: Perlman, D. ): Fermentation Advances, pp. 3--14. New York: Academic Press. 1969. : Biochem. J. 112, 331 (1969). , Jr. 145--166. New York: John Wiley 1972. : In: Wingart, L.

The value of a constant in the general model called the "consumption activity coefficient" (apparent coefficient of growth activity) was determined for each growth phase. The versatile equations obtained were applied to analyse the conditions in batch and continuous fermentations (Kono and Asai, 1969a, 1969b). An attempt was made to analyse the population characteristics of contaminants and mutants during continuous growth. The original equations were later extended to obtain general expressions for the analysis of relationships between cell growth and product formation.

B) On-line Operation . . . . . . . . . . . 4. Computers and Programming Languages . . . . . . a) Off-line Processes . . . . . . . . . . . b) On-line Processes . . . . . . . . . . . 5. Data-Analysis-Oriented Use of the Computer . . . . . a) Layout of Facilities . . . . . . . . . . . b) Computer and Software Capabilities . . . . . . . c) Computer Program . . . . . . . . . . . d) Functional Considerations .

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