By F.J. Dixon, Henry G. Kunkel (Eds.)

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Extra resources for Advances in Immunology, Vol. 16

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This table also includes the subclass to which each antigen is restricted, It was unfortunate that this subclass distribution was entirely ignored in thc preparation of the “new” numbering nomenclature system. TABLE VI HIL\VY-CNAIN ALMTYPESA N D 1 h L A T I O N IMMUNOGLOBULIN CLASSESAND SUBCLASSES IMMUNOGLCIIIULIN Nomenclature New Gm markers 1 2 3 4 5 Original a X b w or b4 f b and b’ 6 C 7 8 r e P bn 9 10 11 12 13 14 15 16 17 1s 19 20 21 22 23 L4 by b3 b4 S t z Rouen 2 ltouen 3 Sail Francisco 2 g IgGl IgGl IgGl IgGl 1gg3 1gg3 IgGl 1gg3 1gg3 1gg3 1gg3 1gg3 1gg3 1gg3 IgGl IgGl ?

Anti-galactomannan 38 J. R . NATVIG AND H. G. KUNKEL from an accumulation of the iron. In a somewhat analogous fashion the anti-lipoproteins interfere with lipid transport and cause lipid accumulations in various organs resulting in malfunction. Several of these have been studied in the authors’ laboratories, and lipid deposits in the skin are a frequent finding. In one case the deposits were extremely widespread including organs such as thc liver and spleen. In this instance the deposits were surrounded by plasma cells.

Primate sera frequently have the human IgC3 Fc antigen which was used above. In contrast, the very strong human IgC3 F(ab’), antigen is not detected in primate sera by precipitation techniques. The accumulated evidence suggests that the IgG subclasses as well as some of the genetic variants developed prior to the dissociation of the human and subhuman primate species. However, further work is needed to prove these relationships. 32 J. B. NATVIG AND H. G . , 1969a): Gm(a) peptide: Old World monkey peptide: Non-c, peptide : Asp-Glu-Leu-Thr-Lys Glu-Glu-Leu-Thr-Lys Glu-Glu-Met-Thr-Lys II.

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