By Gilles Grateau, Robert A. Kyle, Martha Skinner

This authoritative quantity includes 179 chapters by means of foreign specialists on contemporary advancements in our figuring out of amyloid proteins, protein folding problems, and new and proposed scientific trials in amyloidosis. issues comprise detection and characterization options; organic capabilities; genetics; problems, prognosis, and coverings, together with organ transplants and drug remedies; effects from large scientific stories; and epidemiology. this can be a worthy source for clinicians who deal with sufferers with systemic and localized varieties of amyloidosis, and for researchers in biochemistry, neurobiology, and phone biology.

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1996) High-performance liquid chromatography method with light-scattering detection for measurements of lipid class composition: analysis of brains from alcoholics. J. Chromatogr. B Biomed. Appl. 681: 213-8. DISAGGREGATION EXPERIMENTS AS A TOOL TO DETECT PROTOFIBRILLAR INTERMEDIATES Martino Calamai', Claudio Canale", Annalisa Relini", Massimo Stefani'", Fabrizio Chiti'" and Christopher M Dobson' 'Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. "Dipartimento di Fisica, Università di Genova, Via Dodecaneso 33, 16146, Genova, Italy.

Strong evidences indicate that amyloid β-peptide accumulation represents an early event of Alzheimer's disease (1). The fact that mutations in the amyloid protein precursor gene are associated with Alzheimer's disease is a strong indication of the importance of amyloid in the pathogenesis of the disease. The delineation of the amyloid β-peptide hypothesis predicts therapeutics based on preventing the peptide misfolding and aggregation (2). It was previously demonstrated that polyelectrolyte-fluorosurfactant complexes are able to dissolve amyloid plaques in sections of animal tissue and to convert β-sheet into α-helix structures (3, 4).

TISSUE DETECTION AND CHARACTERIZATION OF AMYLOID- IS PROTEOMICS THE ANSWER? 1 3 2 Maria M. Picken , Vanitha Thulasiraman , Roger N. , Fremont, CA, USA. Amyloidosis is a diverse group of diseases characterized by extra-cellular tissue deposits of abnormally folded proteins that are generically termed amyloid and that occur in one or many organs. The gold standard of diagnosis is based on detection of deposits in tissues and is based on either a histological approach using affinity to Congo red (which under polarized light produces an apple-green birefringence), or by the detection of fibrillar deposits using electron microscopy (1).

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