By Thomas Jostock (auth.), Mohamed Al-Rubeai (eds.)
Engineered antibodies at present symbolize over 30% of biopharmaceuticals in scientific trials and their overall around the world revenues proceed to extend considerably. the significance of antibody functions is mirrored of their expanding scientific and business functions in addition to within the development of validated and rising creation techniques. This quantity offers exact insurance of the new release, optimization, characterization, creation and functions of antibody. It offers the mandatory theoretical heritage and outline of equipment for the expression of antibody in microbial and animal phone cultures and in transgenic animals and vegetation. there's a powerful concentrate on these matters regarding the creation of intrabodies, bispecific antibody and antibody fragments and likewise to novel functions in melanoma immunotherapy.
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Extra info for Antibody Expression and Production
Fussenegger, M. (1999) A novel autoregulated proliferation-controlled production process using recombinant CHO cells. Biotechnol Bioeng, 65, 144–50. , Eppenberger, H. , Werner, R. G. & Fussenegger, M. (2002) Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-x(L) on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media. Biotechnol Bioeng, 80, 706–16. , Friedrich, K. & Wurm, F. M. (2001) Transient gene expression: recombinant protein production with suspension-adapted HEK293-EBNA cells.
Science, 301, 1244–6. Hanania, E. , Bodzin, L. , Palsson, B. O. & Koller, M. R. (2005) Automated in situ measurement of cell-specific antibody secretion and laser-mediated purification for rapid cloning of highly-secreting producers. Biotechnol Bioeng, 91, 872–6. Holmes, P. & Al-Rubeai, M. (1999) Improved cell line development by a high throughput affinity capture surface display technique to select for high secretors. J Immunol Methods, 230, 141–7. Ishaque, A. & Al-Rubeai, M. (2002) Role of vitamins in determining apoptosis and extent of suppression by bcl-2 during hybridoma cell culture.
Biotechnol Bioeng, 78, 217–28. Kim, N. S. & Lee, G. M. (2002b) Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression. J Biotechnol, 95, 237–48. Knopf, H. P. (2008) Keynote: speed to patient/market as key for success. BioPharm SCALE-UP. Geneva, Switzerland. Kwaks, T. , Sewalt, R. , Satijn, D. , Brons, J. , Kruckeberg, A. , Kelder, A. & Otte, A. P. (2003) Identification of anti-repressor elements that confer high and stable protein production in mammalian cells.