By Richard T. Walker (auth.), Erik De Clercq, Richard T. Walker (eds.)

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10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 30 B. G. Johansson, J. Antimicrob. , 14, Suppl. A, 5 (1984). J. Hochsladt, Crit. Rev. Biochem. ~, 259 (1974). D. -oIiver, Int. Rev. , 42, 287 (1975). H. Prusoff, Biochim. Biophy~Ac~ 3~5 (1959). C. , Proc. Soc. E;:ZP:-Biol. , 107, 142 (1961). E. ~8, 396 (1962). E. Kaufman, Proc. Soc. Exp. BioI. , 109, 251~1962). S. , 4415 (1979). -E. De Clercq, J. Descamps, P. J. S. T. Yalker, Proc. Natl. Acad. , USA, 76, 2947 (1979).

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24, 134 (1983). C. A. C. H. Verheyden, J. , 76, 180 (1987). S. , ~, 307 (1985). DESIGN OF ANTI-VIRAL AGENTS OTHER THAN NUCLEOSIDE ANALOGUES Stanley M. K. INTRODUCTION It is generally accepted that, by the very nature of the invading organisms and their interactions with the host, the search for anti-viral compounds is going to be much more difficult than the corresponding searches for anti-bacterial and anti-fungal substances. g. g. ofloxacin). g. only fluconazole) related to ketoconazole have emerged as compounds that may take up a noteworthy position in the market place.

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